Well, to be more precise, if you want to present well, learn to be a good presenter using PowerPoint and then start experimenting with other options.
If you are a good presenter, you can present with PowerPoint, Prezi, without a screen, with a flip chart, or with interactive graphics. If you are not a good presenter, you will not be any better if you use the latest 3D, sound-a-round, animated, virtual presence.
The key to any presentation is the presenter. The reason that so many people give bad presentations with PowerPoint is that the presenter has not mastered the skills of presenting and has not created the right message/story. PowerPoint does not make you put too many words on the screen, it does not make you read every word, and it does not make you use bullet points.
In a standard PowerPoint configuration there are 9 default layouts. Of those 9, only 4 have bullet points as a standard option. When bullet points are a standard option, so are 6 other elements, such as a table or chart. So, out of 33 options in the standard set of layouts, just 4 of them include bullets – so why are so many slides using bullets? I think the answer is lack of imagination, lack of training, and lack of skill – but I don’t think it is because PowerPoint makes people do it.
The presenter needs to be clear about the message, they need to think about what they are going to say and how they are going to say it, and then support that with visual and animated aids that have been chosen (or created) to help them get their message across in the best way possible (usually engaging, informative, stimulating, and energising).
Have a look at Hans Rosling present at TED in the clip below. Yes, he makes great use of animated graphics – but then ask the question, would he still have been great if he had used simple slides? I think the answer is yes, the GapMinder material simply make great better. In fact, Rosling is using PowerPoint (or similar) for sections of his presentation.